https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7313 Wed 11 Apr 2018 15:05:43 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22669 Wed 11 Apr 2018 14:16:41 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15201 Wed 11 Apr 2018 12:36:30 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15188 Wed 11 Apr 2018 11:51:25 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16769 Wed 11 Apr 2018 09:29:25 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33370 Wed 09 Feb 2022 15:55:29 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38927  5 years post-diagnosis). Analysis was undertaken for the 6-month supervised exercise portion of the intervention, which involved 100 men aged between 62 and 85 years, 50 in each arm. The primary outcome was cost per quality-adjusted life-years (QALYs). Results: A 6-month supervised exercise intervention for PCa survivors resulted in an incremental cost-effectiveness ratio of AU$64,235 (2018 AUD) at an incremental cost of AU$546 per person and a QALY gain of 0.0085. At a willingness-to-pay of AU$50,000, the probability that the intervention is cost-effective was 41%. Sensitivity analysis showed that maintenance of benefits via a 6-month home-based intervention, immediately following the supervised intervention, lowered the cost per QALY gained to AU$32,051. Discussion: This is the first cost-effectiveness analysis of exercise for PCa survivors. The intervention was effective, but unlikely to be cost-effective at the generally accepted willingness-to-pay of AU$50,000 per QALY. It is likely that evidence to support cost savings from post-intervention outcomes would reveal greater benefits and contribute to a more comprehensive cost-effectiveness analysis. Future RCTs should incorporate longer follow-up durations and collection of data to support modelling to capture future health benefits. Measures of quality of life or utility more sensitive to the impact of physical activity would also improve future economic evaluations.]]> Tue 08 Mar 2022 11:43:17 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36284 Thu 27 Jan 2022 15:57:32 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44701 Thu 20 Oct 2022 15:58:29 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:12268 Sat 24 Mar 2018 08:10:13 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17463 5 yr postdiagnosis on physical functioning.Design, setting, and participants. Between 2010 and 2011, 100 long-term PCa survivors from Trans-Tasman Radiation Oncology Group 03.04 Randomised Androgen Deprivation and Radiotherapy previously treated with androgen-deprivation therapy and radiation therapy were randomly assigned to 6 mo of supervised exercise followed by 6 mo of a home-based maintenance programme (n = 50) or printed educational material about physical activity (n = 50) for 12 mo across 13 university-affiliated exercise clinics in Australia and New Zealand. Intervention: Supervised resistance and aerobic exercise or printed educational material about physical activity. Outcome measurements and statistical analysis: The primary end point was a 400-m walk as a measure of cardiovascular fitness. Secondary end points were physical function, patient-reported outcomes, muscle strength, body composition, and biomarkers. Analysis of covariance was used to compare outcomes for groups at 6 and 12 mo adjusted for baseline values. Results and limitations: Participants undergoing supervised exercise showed improvement in cardiorespiratory fitness performance at 6 mo (−19 s [p = 0.029]) and 12 mo (−13 s [p = 0.028]) and better lower-body physical function across the 12-mo period (p < 0.01). Supervised exercise also improved self-reported physical functioning at 6 (p = .006) and 12 mo (p = 0.002), appendicular skeletal muscle at 6 mo (p = 0.019), and objective measures of muscle strength at 6 and 12 mo (p < 0.050). Limitations included the restricted number of participants undertaking body composition assessment, no blinding to group assignment for physical functioning measures, and inclusion of well-functioning individuals. Conclusions: Supervised exercise training in long-term PCa survivors is more effective than physical activity educational material for increasing cardiorespiratory fitness, physical function, muscle strength, and self-reported physical functioning at 6 mo. Importantly, these benefits were maintained in the long term with a home-based programme with follow-up at 12 mo. Clinical trial registry: The effect of an exercise intervention on cardiovascular and metabolic risk factors in prostate cancer patients from the RADAR study, ACTRN: ACTRN12609000729224.]]> Sat 24 Mar 2018 08:04:06 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26742 Sat 24 Mar 2018 07:24:48 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22711 Sat 24 Mar 2018 07:15:29 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34907 interaction = -1.3 s, 95% confidence interval [CI] -2.6 to 0.0), whole-body lean mass (ß_interaction = 1194 g, 95% CI 234 to 2153) and ASM mass (ß_interaction = 562 g, 95% CI 49 to 1075), and approached significance for fat mass (ß_interaction = -1107 g, 95% CI -2346 to 132), with greater benefits for men previously on long-term ADT. At 6 months, the intervention effects on chair rise time -1.5 s (95% CI -2.5 to -0.5), whole-body lean mass 824 g (95% CI 8 to 1640), ASM mass 709 g (95% CI 260 to 1158), and fat mass -1377 g (95% CI -2156 to -598) were significant for men previously on long-term ADT, but not for men on short-term ADT. At 12 months, the intervention effects for men on long-term ADT remained significant for the chair rise, with improved performance (-2.0 s, 95% CI -3.0 to -1.0) and increased ASM (537 g, 95% CI 153 to 921). Time on ADT did not moderate the exercise effects on muscle strength, nor did time since ADT cessation moderate any intervention effects. Similarly, testosterone and baseline values of the outcome had negligible moderator effects. Conclusions: Men with PCa previously treated long-term with ADT respond more favourably to exercise in terms of lower body muscle performance and body composition (lean and fat mass, and ASM) than those with short-term ADT exposure. As a result, men who were formerly on long-term androgen suppression regimens should be especially prescribed exercise medicine interventions to alleviate residual treatment-related adverse effects.]]> Fri 01 Apr 2022 09:25:19 AEDT ]]>